Pharmacology Mnemonics - Flash Cards

Name: Iodine

Class:

Mechanism: 80% contained in thyroglobulin.

Absorption:

Dist.:

Metabolism.:

Excretion, t½:

Toxicity/S.E.s:

Utility:

Special Features: Deficiency ® endemic goiter. Excess (>20 x RDA) ® blocked organification of iodine ® myxedema.

Name: Vitamin B₁₂ (Cyanocobalamin)

Class:

Mechanism: Necessary for folate Metabolismolism and DNA synth. Maintains myelinization of spinal cord tracts.

Absorption:

Dist.:

Metabolism.:

Excretion, t½:

Toxicity/S.E.s:

Utility:

Special Features: Vegan diet ® deficiency ® megaloblastic pernicious anemia and degeneration of posterolateral spinal cord tracts. If patient is deficient in B₁₂ and folate, replace B_12­ first to avoid irreversible neuro damage. Liver damage ® ­ need.

Name: Biotin

Class:

Mechanism: Incorporated in coenzyme A.

Absorption:

Dist.:

Metabolism.:

Excretion, t½:

Toxicity/S.E.s:

Utility:

Special Features: Some antibiotics kill gut microbes that synthesize biotin.

Name: Vitamin B₃ (Niacin)

Class:

Mechanism: Incorporated into NAD and NADP.

Absorption:

Dist.:

Metabolism.:

Excretion, t½:

Toxicity/S.E.s:

Utility:

Special Features: Deficiency ® pellagra (dementia, dermatitis, diarrhea). Penicillamine, hydralazine, and isoniazid complex w/B₆ ® ¯ B₆. B₆ is a cofactor of tryptophan ® nicotinic acid conversion. Results in ¯ B₃.

Name: Vitamin B₆ (Pyridoxine)

Class:

Mechanism: Derivatives serve as coenzymes in many intermed. rxns.

Absorption:

Dist.:

Metabolism.:

Excretion, t½:

Toxicity/S.E.s: Megadose—severe (often irreversible) sensory neuropathy

Utility:

Special Features: Deficiency ® cheilosis, glossitis, dermatitis, peripheral neuropathy. Liver damage ® ­ need. Penicillamine, hydralazine, and isoniazid complex w/B₆ ® ¯ B₆. B₆ is a cofactor of tryptophan ® nicotinic acid conversion. Results in ¯ B₃. Pregnancy ® ­ B₆ demand.