Pharmacology Mnemonics - Flash Cards

Name: Ofloxacin (Floxin)

Class: Fluorinated quinolone

Mechanism: Inhib bact. DNA gyrase (topoisomerase II). Bactericidal.

Absorption: Oral admin.

Distrib.: Good tissue penetration.

Metabolism.:

Excretion, t½:

Toxicity/S.E.s: Usu. not severe. GI, CNS. Not for pregnant or nursing women or prepubertal children.

Utility: UTIs due to Enterobacteriaceae, Enteroccus, Staph, Pseudomonas. Infectious diarrhea.

Special Features: Broader spectrum than nonfluorinated quinolones. For diarrhea, treat until symptoms resolve, or no longer than 3 days.

Name: Ciprofloxacin (Cipro)

Class: Fluorinated quinolone

Mechanism: Inhib bact. DNA gyrase (topoisomerase II). Bactericidal.

Absorption: Rapid absorption after oral admin.

Distrib.: Good tissue penetration. Poor CSF.

Metabolism.: Partial hepatic Metabolism.

Excretion, t½: Glomerular filtration, secretion. Also feces, bile, sputum. 4 hr.

Toxicity/S.E.s: Usu. not severe. GI, CNS, arthropathy. Not for pregnant or nursing women or prepubertal children.

Utility: Upper and lower UTIs, DOC for Pseudomonas UTIs. Active against aerobic gram- bacilli, H. influenzae, Neisseria. Good for several causes of infectious diarrhea, osteomyelitis, and patients w/CF.

Special Features: Broader spectrum than nonfluorinated quinolones. For diarrhea, treat until symptoms resolve, or no longer than 3 days.

Name: Norfloxacin (Noroxin)

Class: Fluorinated quinolone

Mechanism: Inhib bact. DNA gyrase (topoisomerase II). Bactericidal.

Absorption: Oral admin.

Distrib.: Good tissue penetration.

Metabolism.:

Excretion, t½:

Toxicity/S.E.s: Usu. not severe. GI, CNS. Not for pregnant or nursing women or prepubertal children.

Utility: UTIs due to Enterobacteriaceae, Enteroccus, Staph, Pseudomonas. Infectious diarrhea.

Special Features: Broader spectrum than nonfluorinated quinolones. For diarrhea, treat until symptoms resolve, or no longer than 3 days.

Name: Norfloxacin (Noroxin)

Class: Fluorinated quinolone

Mech.: Inhib bact. DNA gyrase (topoisomerase II). Bactericidal.

Absorption: Oral admin.

Distribution: Good tissue penetration.

Metab.:

Excretion, t½:

Toxicity/S.E.s: Usu. not severe. GI, CNS. Not for pregnant or nursing women or prepubertal children.

Utility: UTIs due to Enterobacteriaceae, Enteroccus, Staph, Pseudomonas.

Special Features: Broader spectrum than nonfluorinated quinolones.

Name: Ciprofloxacin (Cipro)

Class: Fluorinated quinolone

Mech.: Inhib bact. DNA gyrase (topoisomerase II). Bactericidal.

Absorption: Rapid absorption after oral admin.

Distribution: Good tissue penetration. Poor CSF.

Metab.: Partial hepatic metab.

Excretion, t½: Glomerular filtration, secretion. Also feces, bile, sputum. 4 hrs.

Toxicity/S.E.s: Usu. not severe. GI, CNS, arthropathy. Not for pregnant or nursing women or prepubertal children.

Utility: Upper and lower UTIs, DOC for Pseudomonas UTIs. Active against aerobic gram- bacilli, H. influenzae, Neisseria. Good alternate. for several causes of infectious diarrhea, osteomyelitis, and patients w/CF.

Special Features: Broader spectrum than nonfluorinated quinolones.