Showing posts with label Ganglionic Blocking Agent. Show all posts
Showing posts with label Ganglionic Blocking Agent. Show all posts

Trimethaphan (Arfonad)

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Name: Trimethaphan (Arfonad)

Class: Ganglionic Blocking Agent

Mech.: Blocks nerve transmission at parasympathetic and sympathetic ganglia. Direct peripheral vasodilation. Non-selective.

Absorption: Only IV admin.

Dist.:

Metab.:

Excretion, : Short duration of action.

Toxicity/S.E.s: Hypotension—requires constant monitoring of blood pressure during administration.

Utility: Treat hypertensive emergencies. Produce controlled hypotension during surgery.

Special Features:

 

Mecamylamine (Inversine)

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Name: Mecamylamine (Inversine)

Class: Ganglionic Blocking Agent

Mech.: Blocks nerve transmission at parasympathetic and sympathetic ganglia. Non-selective.

Absorption: Oral ® complete absorption.

Dist.:

Metab.:

Excretion, :

Toxicity/S.E.s:

Utility: Treat severe hypertension.

Special Features: