Name: Guanabenz (Wytensin)
Class: Centrally Acting Antiadrenergic Agent
Mechanism: Stimulates inhibitory a2 receptors in central cardiovasc pathways involving EPI or NE. a2 are G-protein coupled to inhibit adenylyl cyclase ®
¯ cAMP ® ¯ central symp. activity.
Absorption: Oral.
Dist.: Acts at medullary and spinal sites.
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Prominent sedation, dry mouth, depression in those so inclined, constipation. May potentiate actions of other CNS depressants. Rebound hypertension, nervousness, insomnia if w/drawn too quickly.
Utility: Treat hypertension.
Special Features: Direct a2 activation. CV reflexes remain intact; normal homeostatic responses to exercise are maintained.