Name: Allopurinol (Zyloprim)
Class: Anti-Gout Agent
Mechanism: Inhibits xanthine oxidase ® ¯ production of uric acid.
Absorption: Well absorbed orally.
Dist.:
Metabolism.: Metabolism. by xanthine oxidase to a longer acting active Metabolismolite.
Excretion, t½:
Toxicity/S.E.s: GI intolerance, skin rash.
Drug Interactions: Inhib. Metabolism. of oral anticoagulants. Xanthine oxidase inactivates 6-mercaptopurine & azathioprine (cancer chemotherapeutic drugs). \ doses must be lowered when patient takes allopurinol.
Utility: Treat chronic tophaceous gout, gout patients w/high excretion of uric acid, patients who cannot use probenecid or sulfinpyrazone, recurrent renal uric acid stones, renal impairment, grossly elevated serum acid concentrations (>13 mg/dL). Use also w/cancer chemotherapy to prevent urate nephropathy.
Special Features: