Name: Sulfinpyrazone (Anturane)
Class: Anti-Gout Agent (Uricosuric Agent)
Mechanism: Blocks proximal tubular reabsorption of uric acid.
Absorption:
Dist.:
Metabolism.:
Excretion, t½: Rapidly excreted by the kidneys.
Toxicity/S.E.s: GI irritation (not severe). Skin rash. Rare aplastic anemia.
Utility: Treat gout via increased urinary excretion of uric acid.
Special Features: At low doses, sulfinpyrazone blocks proximal tubule secretion
of uric acid.