Name: Azathioprine (Imuran)
Class: Immunosuppressant (AntiMetabolismolite)
Mechanism: Converted to 6-mercaptopurine (thiol analog of hypoxanthine) ® inhib. of purine synth. ® cytotoxicity to dividing cells ® ¯ lymphocyte proliferation ® inhib. of cellular and humoral immunity.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Bone marrow depression (main toxicity), n/v/d, hepatotoxicity.
Utility: Primarily used in maintenance of remission in acute lymphoblastic leukemia.
Special Features: