Name: Urokinase (Abbokinase)
Class: Antithrombotic Agent (Thrombolytic Agent)
Mechanism: Urinary-type single chain plasminogen activator. Isolated from cultured human kidney cells.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Hemorrhage.
Utility: Treat acute MI (w/in 6 hr. of symptoms), massive PE, acute proximal vein thromboses, occlusion of dialysis access sites and indwelling catheters, occlusion of prosthetic heart valves.
Special Features: Best results in pts. that receive therapy < style=""> Generally non-antigenic. Does not cause allergic rxns.