Pharmacology Mnemonics - Flash Cards

Name: Enalapril (Vasotec)

Class: ACE Inhibitor

Mechanism: Inhib. production of angiotensin II ® block of vasoconstriction and aldosterone stim. ® ¯ TPR, ¯ Na⁺/H₂0 retention ® ¯ BP. Also blocks inactivation of bradykinin ® vasodilation. Diminishes normal ­ in epinephrine and aldosterone seen in CHF.

Absorption:

Dist.:

Metabolism.:

Excretion, t½:

Toxicity/S.E.s: Postural hypotension, renal insufficiency, hyperkalemia, persistent dry cough, rash, angioneurotic edema. C/i in 2^nd & 3^rd trimesters of pregnancy. Prob. not a great idea for 1^st trimester either.

Utility: Treat HTN, CHF, MI.

Special Features: Inactive prodrug. Converted to enalaprilat (acts like captopril).