Name: Losartan (Cozaar)
Class: Angiotensin II Antagonist
Mechanism: Competitive inhib. of angiotensin II ® smooth muscle relaxation (vasodilation), ¯ Na+ & H20, ¯ plasma volume ® ¯ BP.
Absorption: Oral.
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Hyperkalemia, fetal toxicity (c/i in 2nd & 3rd trimesters).
Utility: Treat hypertension.
Special Features: Angioneurotic edema and dry cough of ACE inhibitors not manifested.