Name: Sotalol (Betapace)
Class: Antidysrhythmic Agent (Class III)
Mechanism: Blocks rapid outward K+ current (delayed rectifier) ® prolonged repolarization and action potential ® effective refractory period. Little effect on rate of depolarization. L-isomer is a potent b-blocker.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Rel. low rate of adverse effects. DILQT synd., sinus bradycardia.
Utility: Long-term therapy to decrease the rate of sudden death following acute MI. Modest ability to suppress ectopic beats and ¯ O2 demand. Strong antifibrillary effect. Prevents arrhythmia and decreases mortality in pts. w/sustained ventricular tachycardia.
Special Features: