Name: Phenelzine (Nardil)
Class: Psychopharmacological Agents (Antidepressant) (MAOI) (Hydrazine Deriv.)
Mechanism: Inhib. of MAO ® central build-up of NE, 5HT, DA.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Headache, drowsiness, dry mouth, weight gain, postural hypotension (central a2), sexual disturbances, liver damage, hyperpyrexia. Interactions w/TCAs, dextromethorphan, meperidine, and tyramine can be fatal.
Utility: Treat depression.
Special Features: Usu. prescribed as alt. only when other drugs are ineffective.