Name: Selegiline (Deprenyl, Eldepryl)
Class: Antiparkinsonian agent (MAO-B Inhibitor)
Mechanism: Low doses ® selective inhibition of MAO-B ® prolonged action of endogenous DA and L-Dopa effects.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Mild wearing off & on/off phenomena. However, long-term use may ® shorter time to develop adverse responses to L-Dopa. In late PD, coadmin. w/L-Dopa may ® exacerbation of adverse L-Dopa effects. C/I in patients taking meperidine (® stupor, rigidity, agitation, hyperthermia).
Utility: Relieves symptoms of Parkinson’s Disease.
Special Features: Doesn’t diminish freq. of late PD problems nor postpone their development.