Name: Alendronate (Fosamax)
Class: Bisphosphonate
Mechanism: Structure sim. to inorganic pyrophosphate. Impairs formation and dissolution of calcium phosphate crystals. Alters number/activity of osteoclasts (1° effect) ® slowed bone resorption. Slows formation and dissolution of hydroxyapatite crystals.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s:
Utility: Increases bone mass in spines and hips of postmenopausal women ® ¯ incidence of fractures.
Special Features: Efficacy maintained over at least 3 yr.