Name: Thiazides
Class: Diuretic
Mechanism: ¯ reabsorption of Na+ in distal tubule by inhibition of a Na+/Cl- cotransporter on the luminal membrane. Promotes reabsorption of Ca2+ ® ¯ Ca2+ in urine.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Potassium depletion, hyperuricemia, volume depletion, hypercalcemia, hyperglycemia, hypersensitivity.
Utility: Treat hypertension, congestive heart failure, renal impairment, hypercalciuria, diabetes insipidus.
Special Features: