Name: Furosemide (Lasix)
Class: Loop Diuretic
Mechanism: Inhib. Na+/K+/Cl- cotransport of the luminal membrane in the ascending limb of the loop of Henle ® ¯ reabsorption of Na+, K+, & Cl-. Increases conc. of Ca2+ in urine.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Ototoxicity, hyperuricemia, acute hypovolemia, potassium depletion.
Utility: DOC for reducing acute pulmonary edema of congestive heart failure. Rapid onset, so useful in emergency situations. Treat hypercalcemia.
Special Features: