Name: Pamidronate (Aredia)
Class: Bisphosphonate
Mechanism: Structure sim. to inorganic pyrophosphate. Impairs formation and dissolution of calcium phosphate crystals. Alters number/activity of osteoclasts (1° effect) ® slowed bone resorption. Slows formation and dissolution of hydroxyapatite crystals.
Absorption: IV admin. only
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s:
Utility: DOC for mod.-severe hypercalcemia assoc. w/malignant neoplasms. Treat Paget’s disease of bone. Must be used in conjnxn w/adequate hydration and urinary output.
Special Features: 100x more potent than etidronate, more efficacious, and does not affect normal bone mineralization at normal therapeutic concentrations.