Name: Clofibrate (Atromid-S) mnemonic
Class: Blood Lipid-Lowering Agent (Fibric Acid Derivative)
Mechanism: catabolism of VLDL, in part 2° to activity of lipoprotein lipase in adipose tissue. Moderate ¯ in TG & VLDL. Zero-mild ¯ in cholesterol. Zero-mild in HDL. Mild or ¯ in LDL.
Absorption:
Dist.:
Metabolism.: Glucuronide conjugation.
Excretion, t½: Renal excretion.
Toxicity/S.E.s: Generally well tolerated. Gallstones, nausea, diarrhea, abdominal discomfort. Displaces weakly acidic drugs (T3, T4, warfarin, phenytoin) from plasma proteins. Binds cholestyramine.
Utility: Treat severe hyperlipidemia IV refractory to gemfibrozil or niacin.
Special Features: Does not appear to decrease frequency of CHD-related incidents.