Name: Ticlopidine (Ticlid)
Class: Antithrombotic Agent (Antiplatelet Agent)
Mechanism: Unknown. Through some effect on platelet membranes, blocks ADP-induced aggregation. Interacts w/membrane glycoprotein IIb/IIIa.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Diarrhea, GI cramping, rash, LDL & VLDL, leukopenia, agranulocytosis, pancytopenia.
Utility: Treat thromboses in patients unable to take aspirin. May be more effective than aspirin in 2° prevention of stroke in pts w/previous TIA.
Special Features: Several days required for effects to develop. Effects persist for several days after cessation of treatment. As effective in E as in G. Antithrombotic use is primarily for arterial thromboses.