Name: Nicotinic Acid (Niacin)
Class: Blood Lipid-Lowering Agent
Mechanism: Reduces synth. rate of VLDL. Inhib. lipolysis of TG in adipocytes. Large ¯ in TG. Moderate ¯ in cholesterol & VLDL. Mild ¯ in LDL. Zero-moderate in HDL.
Absorption:
Dist.: Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Cutaneous flushing (92%), itching (49%), rashes (20%). Reduce w/aspirin pretreatment, admin. after meals, small init. dose gradually increased in size. Pruritis, dry skin, pigmentation, hepatotoxicity, n/v, dyspepsia, peptic ulceration, urinary frequency, dysuria, gout. High doses ® hepatic/pancreatic dysfxn. Coadmin. anti-hypertensives ® dizziness, syncope. Sustained-release preparations more commonly assoc. w/hepatotoxicity, dry eyes, pigmentation, hyperglycemia.
Utility: Prob. DOC for hyperlipidemias IV and V. Very useful for III. Can be used for II. Synergy w/resins.
Special Features: