Name: Protamine Sulfate
Class: Anticoagulant Antagonist
Mechanism: Binds tightly to heparin and rapidly reverses its effects. Also interacts w/platelets, fibrinogen, and other plasma proteins ® anticoagulant effect.
Absorption: IV infusion—slow rate.
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s:
Utility: Treat life-threatening hemorrhage 2° to heparin use.
Special Features: Use minimal effective dose.