Name: Phenolphthalein (Ex-Lax)
Class: Laxative (Contact Cathartic) (Diphenylmethane Cathartic)
Mechanism: Act on colon ® peristalsis. Effects take at least 6 hr. to manifest.
Absorption: Oral ® 15% absorption
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Fluid and electrolyte depletion, abdominal cramping, ashes, osteomalacia. Potential for atonic colon w/prolonged use.
Utility: Laxative.
Special Features: Indiv. effective doses vary 4-8x. Acid/base indicator ® pink/red urine. Not effective in pts. who lack bile. Contact cathartics are most commonly involved in prolonged cathartic abuse. Should never be used > 1 wk of regular therapy. Not recommended for initial therapy.