Name: Vitamin B6 (Pyridoxine)
Class:
Mechanism: Derivatives serve as coenzymes in many intermed. rxns.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Megadose—severe (often irreversible) sensory neuropathy
Utility:
Special Features: Deficiency ® cheilosis, glossitis, dermatitis, peripheral neuropathy. Liver damage ® need. Penicillamine, hydralazine, and isoniazid complex w/B6 ® ¯ B6. B6 is a cofactor of tryptophan ® nicotinic acid conversion. Results in ¯ B3. Pregnancy ® B6 demand.