Name: Minoxidil (Loniten)
Class: CHF Rx (Vasodilator) (Antihypertensive)
Mechanism: Direct arteriolar vasodilation ® ¯ TPR ® reflex in HR & CO.
Absorption: Oral.
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Severe tachycardia. Serious Na+ & H2O retention ® volume overload, edema, CHF. Hypertrichosis.
Utility: Treat severe-malignant HTN refractory to other drugs. Male pattern baldness.
Special Features: Reflex tachycardia may be severe, requiring concomitant use of a diuretic and a b-blocker.