Name: Diphenoxylate-Atropine (Lomotil)
Class: Opioid (Antidiarrheal)
Mechanism: Increased gastric tone ® delayed gastric emptying. tone and ¯ propulsive peristaltic waves in large intest. ® ¯ gut motility. Effects due to inhib. of ACh release by neurons in the intest. wall. Naloxone sensitive.
Absorption: Oral
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Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Recommended dose ® dizziness, drowsiness, mild euphoria. Excessive doses ® pronounced euphoria, potentially serious respiratory depression (may not be evident until 12-30 hr later). ¯ peristalsis ® ¯ evacuation of bacteria and toxins. Use w/great caution in kids. Potentiates effects of barbiturate, tranquilizers, alcohol, other narcotics. Hypertensive crisis w/MAOI.
Utility: Antidiarrheal.
Special Features: