Name: Doxapram (Dopram)
Class: Analeptic
Mechanism: Direct stim. of medullary resp. centers ® stimulation of respiration. May stim. resp. via reflex effect on periph. chemoreceptors.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Large doses ® tonic-clonic seizures.
Utility: Occasionally used to treat acute resp. failure assoc. w/COPD. Prev. used to treat resp. depression assoc. w/CNS depressant overdose. No longer recommended for this use due to high potential for seizures.
Special Features: