Name: Isoflurane (Forane)
Class: General Anesthetic (Halogenated Hydrocarbon)
Mechanism: Stabilizes membranes of excitable tissue ® inhibition of action potential (primarily pre-synaptic blockade of synaptic transmission).
Absorption:Inhaled. Interm. blood solubility®Interm. onset of effect (BGPC = 1.4). MAC = 1.40.
Dist.: Dissolves in blood. Organs w/high perfusion are most affected.
Metabolism.: Very little liver Metabolism. (2%).
Excretion, t½:
Toxicity/S.E.s: Moderately irritating. Low level of cardiac depression. Depresses circulation. Low potential for arrhythmia.
Utility: Induces general anesthesia.
Special Features: Lowest toxicity of the volatile liquids. Non-flammable. Satisfact. analgesia, good relaxation.