Name: Cefaclor (Ceclor)
Class: Second Gen. Cephalosporin
Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.
Absorption: Oral.
Distribution: Poor CSF.
Metab.:
Excretion, t½:
Toxicity/S.E.s: Hypersensitivity (some cross-sensitivity to pen.), superinfection, renal damage (worse if comb. w/aminoglycs.)
Utility: Resp. and middle ear infections (H. influenzae, M. catarrhalis)
Special Features: More gram- efficacy than first gen. Less gram+ cocci efficacy than first gen. b-lactamase resistance. Problem w/bacterial resistance.