Name: Phenazopyridine (Pyridium)
Class: Analgesic (not an antibiotic)
Mech.: Analgesic effect on urinary tract mucosa.
Absorption:
Distribution:
Metab.:
Excretion, t½: 90% excreted in urine w/in 24 hrs.
Toxicity/S.E.s: GI, headaches. Not for use w/renal insufficiency or severe hepatitis. Hemolytic anemia. Cancer in rats. Stains urine, skin, sclera, and contact lenses red-orange.
Utility: Relief of dysuria and urethral irritation assoc. w/acute cystitis, trauma, surgery, catheterization, endoscopy.
Special Features: When used w/antibacterial agent, should be discontinued after 48 hr. Should never be used on long-term basis to mask undiagnosed urinary tract pain.