Name: Neomycin (Mycifradin)
Class: Aminoglycoside
Mech.: O2 dependent uptake ® inhib. of protein synth by binding to 30S rib. subunit ® leaky membranes. Bactericidal.
Absorption: Very little oral absorption. Topical.
Distribution: Limited to extracellular space. Poor CSF, ocular. No placenta.
Excretion, t½:
Toxicity/S.E.s: Parenteral ® severe ototoxicity and nephrotoxicity.
Utility: Topical treatment of superf. sensitive skin and eye infections. Preoperative prophylaxis for bowel surgery.
Special Features: Resistance 1° due to plasmid-med. mod. of aminoglyc. Also alter. of transport system, mutation of rib. subunit.