Name: Tacrine (Cognex)
Class: Anticholinesterase Agent: Acridinamine
Mech.: Blocks AChE and BuChE. Inhib. M1 and M2 receptors. Weak nicotinic blocker. release of ACh from nerve endings.
Absorption:
Dist.: Good CNS.
Metab.:
Excretion, t½:
Toxicity/S.E.s: Reversible liver damage. Avoid in cases of asthma, coronary insufficiency, peptic ulcers.
Utility: Alzheimer’s disease
Special Features: