Name: Pyrazinamide
Class: Antitubercular
Mech.: Bactericidal. Unknown mech.
Absorption: Well absorbed orally. Not affected by food.
Distribution: Dist. in total body water.
Metab.: Partially metabolized — hydrolyzed, hydroxylated
Excretion, t½: Glomerular filtration. 8 hrs.
Toxicity/S.E.s: Liver necrosis, hyperuricemia, nausea, vomiting, complication of diabetes management.
Utility: Used to treat TB when there is resistance to other agents. Requires 3 additional effective agents.
Special Features: