Name: Isoflurophate (Floropryl, DFP)
Class: Anticholinesterase Agent: Organophosphate
Mech.: Binds irreversibly to AChE
Absorption:
Dist.: Acts mostly at autonomic sites. Some neuromusc. action.
Metab.:
Excretion, t½: Long-lasting inhibition—days to weeks.
Toxicity/S.E.s: Toxic doses first stim. then depress autonomic ganglia, neuromusc. jxns, and central sites. Treat w/heroic doses of atropine for muscarinic effects, pralidoxime for neuromusc effects.
Utility:
Special Features: Bond btwn drug and AChE must age before becoming irreversible. While bond is aging, drugs such as pralidoxime can reactivate AChE.