Name: Imipenem
Class: b-lactam (Carbapenem)
Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.
Absorption: Oral, IV (painful)
Distribution:
Metab.:
Excretion, t½:
Toxicity/S.E.s: painful injection, allergy, nausea/vomiting, superinfection (diarrhea), reversible blood disorders.
Utility: Combined w/equal amts of cilastatin to block tubular metab. and formation of nephrotoxic compounds. Treats serious nosocomial infections, infections of unknown etiology, mixed infections.
Special Features: Broadest spectrum of all b-lactams. Resistant to penicillinases and most b-lactamases. Resistance develops during treatment.