Name: Ribavirin (Virazole)
Class: Antiviral
Mech.: Purine analog. After phosphorylation, inhibits enzymes involved in guanine nucleotide synth. After further phosph, inhib several viral-specific enzymes involved in DNA synth.
Absorption: Oral bioavail 45%. IV. Aerosol.
Distribution:
Metab.:
Excretion, t½: 40 days
Toxicity/S.E.s: Accumulates in erythrocytes ® hemolytic anemia. Bone marrow suppression. GI, CNS aggravation. Teratogenic and mutagenic in animals. Toxicity avoided w/aerosol admin (for RSV). Antagonizes AZT activity.
Utility: Aerosol form used to treat respiratory syncytial virus. Most important drug for treatment of hemorrhagic fever.
Special Features: