Name: Clindamycin (Cleocin)
Class: Lincosamide
Mech.: Inhib protein synth by binding to 50S rib. subunit. Bacteriostatic.
Absorption: Nearly complete oral absorption. IV.
Distribution: Good into most tissues, including bone. Poor CSF.
Metab.: Hepatic metab.
Excretion, t½: Renal excretion. 2.7 hr.
Toxicity/S.E.s: High incidence of diarrhea. Antibiotic-assoc. pseudomembranous colitis. Skin rashes. Local thrombophlebitis due to IV.
Utility: Alternate to pen. or eryth. in susceptible infections. One DOC for non-CNS anaerobic infections. Used topically for acne.
Special Features: