Pharmacology Mnemonics - Flash Cards

Name: Iodide

Class: Antifungal? Halide?

Mech.:

Absorption:

Distribution:

Metab.:

Excretion, t½:

Toxicity/S.E.s:

Utility: Used as alternate treatment for superficial cutaneous Sporotrichosis.

Special Features:

Name: Griseofulvin (Grifulvin)

Class: Antifungal

Mech.: Binds to microtubules, disrupts mitotic spindle, blocks mitosis. Fungistatic.

Absorption: Always given orally. Erratically absorbed. Fatty meals ® ­ absorption.

Distribution: Binds in high conc. to keratin in areas of skin, hair, nails most affected by dermatophytes.

Metab.:

Toxicity/S.E.s: Headache, rare CNS effects (memory lapse, impaired judgment, blurred vision. Candida superinfection. High doses carcinogenic, teratogenic. Disulfiram-like effect with alcohol. Reduces efficacy of some oral contraceptives.

Utility: Inhibits most dermatophytes and superfic. yeast infections. Treats most types of tinea, ringworm, athletes foot.

Special Features: Cures at the base of the problem. When the cured base grow completely out, patient is cured. Long eradication time. Poor cure rate.

Name: Flucytosine (Ancobon)

Class: Antifungal

Mech.: Converted to 5-fluorouracil in fungi (enzyme not in humans). 5-fluorouracil ® phosph deoxyribose that inhibits thymidylate synth. Fungistatic.

Absorption: Well absorbed orally.

Distribution: Passes BBB (75%) ® good CSF. Aqueous humor, bronchial secretions. Poorly bound by serum proteins.

Metab.:

Excretion, t½: 1° glomerular filtration (unmetab. product). 3-4 hr ® 200 hr w/renal failure. Dose must be adjusted if renal fxn compromised.

Toxicity/S.E.s: Bone marrow depression with anemia, thrombocytopenia, leukopenia. Nausea, rashes, eosinophilisa, severe diarrhea, reversible hepatic dysfxn. Confusion, hallucinations, headache, vertigo, possibly fatal enterocolitis (esp. in comb. w/Amphoter.).

Utility: DOC for Chromomycosis. Used in comb. w/Amph for systemic Candida Albicans.

Special Features: Narrower spectrum than Amphotericin B. Resistance develops rapidly, so usu. used in comb., except to treat Chromomycosis