Pharmacology Mnemonics - Flash Cards

Name: Ticarcillin (Ticar)

Class: Penicillin (Extended spectrum)

Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.

Absorption: IM, IV.

Distribution: Widely distributed, little CSF unless meninges inflamed.

Metab.:

Excretion, t½: Rapidly elim. by kidneys (probenecid blocks excretion), small amt. in bile.

Toxicity/S.E.s: hypersensitivity (1-10%), superinfection., coagulation disorders.

Utility: Gram -. Effective against Pseudomonas, Proteus mirabilus, often used w/aminoglyc.

Special Features: Narrow spectrum. Resistance develops quickly.

Name: Ticarcillin (Ticar)

Class: Penicillin (Extended spectrum)

Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.

Absorption: IM, IV.

Distribution: Widely distributed, little CSF unless meninges inflamed.

Metab.:

Excretion, t½: Rapidly elim. by kidneys (probenecid blocks excretion), small amt. in bile.

Toxicity/S.E.s: hypersensitivity (1-10%), superinfection., coagulation disorders.

Utility: Gram -. Effective against Pseudomonas, Proteus mirabilus, often used w/aminoglyc.

Special Features: Narrow spectrum. Resistance develops quickly.

Name: Oxacillin (Bactocill)

Class: Penicillin (Penicillinase-resistant)

Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.

Absorption: Acid stable. Absorbed orally. IM, IV.

Distribution: Widely distributed, little CSF unless meninges inflamed.

Metab.:

Excretion, t½: Rapidly elim. by kidneys (probenecid blocks excretion), small amt. in bile.

Toxicity/S.E.s: hypersensitivity (1-10%), superinfection.

Utility: Penicillinase-producing staph. infections. Mild infections.

Special Features: Narrow spectrum.

Name: Methicillin (Staphcillin)

Class: Penicillin (Penicillinase-resistant)

Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.

Absorption: Usu. IV for seious infections. IM.

Distribution: Widely distributed, little CSF unless meninges inflamed.

Metab.:

Excretion, t½: Rapidly elim. by kidneys (probenecid blocks excretion), small amt. in bile.

Toxicity/S.E.s: hypersensitivity (1-10%), superinfection.

Utility: Penicillinase-producing staph. infections. Gram +.

Special Features: Narrow spectrum.

Name: Nafcillin (Nafcil)

Class: Penicillin (Penicillinase-resistant)

Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.

Absorption: Poor oral. Usu. IV for seious infections. IM.

Distribution: Widely distributed, little CSF unless meninges inflamed.

Metab.:

Excretion, t½: Rapidly elim. by kidneys (probenecid blocks excretion), small amt. in bile.

Toxicity/S.E.s: hypersensitivity (1-10%), superinfection.

Utility: Penicillinase-producing staph. infections. Gram +.

Special Features: Narrow spectrum. Prob. most effective penicillinase-resist.

Name: Penicillin V

Class: Penicillin (Penicillin G-related)

Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.

Absorption: Acid stable ® good oral absortption.

Distribution: Widely distributed, little CSF unless meninges inflamed.

Metab.:

Excretion, t½: Rapidly elim. by kidneys (probenecid blocks excretion), small amt. in bile.

Toxicity/S.E.s: : hypersensitivity (1-10%), superinfection.

Utility: Mild to moderate infections only: Many gram +, anaerobes, and a few gram -. Most staph. and gram - resistant. Same spectrum as Pen. G, but less active.

Special Features: Narrow spectrum.

Name: Penicillin G

Class: Penicillin (Penicillin G-related)

Mech.: Binds to PBPs, blocks activity of transpeptidases in terminal stages of cell wall formation. Bactericidal.

Absorption: Erratic (30%). Usu. not used orally. I.M or I.V. Prolonged effect with repository preparations (procaine, benzathine (longest)) deep IM.

Distribution: Widely distributed, little CSF unless meninges inflamed.

Metab.:

Excretion, t½: Rapidly elim. by kidneys (probenecid blocks excretion), small amt. in bile.

Toxicity/S.E.s: hypersensitivity (1-10%), painful injection, epilepsy, superinfection.

Utility: Many gram +, anaerobes, and a few gram -. Most staph. and gram - resistant. Prophylactic use (rheumatic fever, strep. infections).

Special Features: Narrow spectrum.