Name: Naltrexone (Trexan)
Class: Opioid Antagonist
Mechanism: Competitive inhib. at opioid receptors.
Absorption: Oral
Dist.:
Metabolism.:
Excretion, t½: Long duration of action.
Toxicity/S.E.s:
Utility: “Maintenance” drug for opioid addicts in rehab. programs. May also decrease alcohol craving in chronic alcoholics.
Special Features:Etiketler: Opioid Antagonist
Name: Naloxone (Narcan)
Class: Opioid Antagonist
Mechanism: Competitive inhib. at opioid receptors.
Absorption: IV
Dist.:
Metabolism.:
Excretion, t½: Duration of action ~ 1 hr.
Toxicity/S.E.s:
Utility: Treat opioid poisoning.
Special Features: May require intermittent dosing, as half life is so short.
Etiketler: Opioid Antagonist