Pharmacology Mnemonics - Flash Cards

Name: Sulfasalazine (Azulfidine)

Class: Sulfonamide (Slow-Acting Antirheumatic Agent)

Mechanism: Comp. inhib. of PABA incorp. into dihydropteric acid ® inhib. of folic acid.

Absorption: Poorly absorbed in GI tract.

Distribution: GI tract

Metabolism.: Hydrolyzed to active form by intest. bacteria.

Excretion, t½: feces

Toxicity/S.E.s: Interferes w/normal flora ® ¯ vit. K synth.

Utility: Active in bowel lumen. Used prior to surgery to reduce microbe population. Treat inflammatory bowel disease, rheumatoid arthritis.

Special Features: Broken down in intestines to liberate 5-aminosalicylate (anti-inflammatory).

Name: Sulfacetamide sodium (Sulamyd Sodium)

Class: Sulfonamide

Mech.: Comp. inhib. of PABA incorp. into dihydropteric acid ® inhib. of folic acid.

Absorption:

Distribution: Ophthalmic application. Penetrates into ocular fluids at high conc.

Metab.:

Excretion, t½:

Toxicity/S.E.s:

Utility: Ophthalmic infections

Special Features: High aqueous concentrations are not irritating.

Name: Silver Sulfadiazine (Silvadene)

Class: Sulfonamide

Mech.: Releases silver ® toxicity for bacteria and fungi.

Absorption:

Distribution: Topical

Metab.:

Excretion, t½:

Toxicity/S.E.s:

Utility: Used topically to reduce infection of burns, but not to treat established infections.

Special Features:

Name: Sulfasalazine (Azulfidine)

Class: Sulfonamide

Mech.: Comp. inhib. of PABA incorp. into dihydropteric acid ® inhib. of folic acid.

Absorption: Poorly absorbed in GI tract.

Distribution: GI tract

Metab.: Hydrolized to active form by intest. bacteria.

Excretion, t½: feces

Toxicity/S.E.s: Interferes w/normal flora ® ¯ vit. K synth.

Utility: Active in bowel lumen. Used prior to surgery to reduce microbe population. Treat inflammatory bowel disease, rheumatoid arthritis

Special Features: Broken down in intestines to liberate 5-aminosalicylate (anti-inflammatory).

Name: Sulfadiazine

Class: Sulfonamide

Mech.: Comp. inhib. of PABA incorp. into dihydropteric acid ® inhib. of folic acid. Bacteriostatic.

Absorption: Rapidly absorbed in GI tract. Parenteral.

Distribution: Widely distrib; good CSF. Crosses placenta.

Metab.: Acetylated in liver

Excretion, t½: Renal filtration, secretion

Toxicity/S.E.s: Hypersensitivity—fever, rash, photosensitivity; UT disturbances— deposition of crystalline aggregates; hematopoetic disorders—dyscrasias

Utility: Uncomplicated UTIs, trachoma (contag. disease of eyelid, conjunct, cornea), nocardiosis (tuberculosis-like infect.), prophylaxis (burnt skin, suppressing recurring UTIs, rheumatic fever)

Special Features: Spectrum—gram +, gram -.