Pharmacology Mnemonics - Flash Cards

Name: Chlorpheniramine (Chlor-Trimeton)

Class: H₁-Histamine Antagonist (OTC)

Mechanism: Inhib. of histamine and histamine receptor interaction.

Absorption: Oral

Dist.:

Metabolism.:

Excretion, t½:

Toxicity/S.E.s: Sedation

Utility: Treat allergic rhinitis.

Special Features:

Name: Astemizole (Hismanal)

Class: H₁-Histamine Antagonist

Mech.: Competitive inhib. of histamine and histamine receptor interaction.

Absorption:

Dist.: No CNS

Metab.:

Excretion, t½: 10-20 days

Toxicity/S.E.s: Increased appetite, weight gain. Overdose ® cardiac arrhythmia.

Utility: Effective against allergic rhinitis and chronic urticaria.

Special Features: No anticholinergic activity.

Name: Terfenadine (Seldane)

Class: H₁-Histamine Antagonist

Mech.: Competitive inhib. of histamine and histamine receptor interaction.

Absorption: Oral

Dist.: No CNS

Metab.:

Excretion, t½:

Toxicity/S.E.s:

Utility: Treat allergic rxns (e.g., hay fever).

Special Features: No anticholinergic activity. Few/no CNS effects. Probably not as effective as older antihistamines. Fails to produce even moderate relief of symptoms in many patients.