Pharmacology Mnemonics - Flash Cards

Name: Amikacin (Amikin)

Class: Aminoglycoside

Mech.: O2 dependent uptake ® inhib. of protein synth by binding to 30S rib. subunit ® leaky membranes. Bactericidal.

Absorption: Poor oral absorption. Usu. IM or IV.

Distribution: Limited to extracellular space. Poor CSF, ocular. No placenta.

Excretion, t½: glomerular filtration. 2 hrs.

Toxicity/S.E.s: Ototox.(aud., vest.)(>than gent or tobr), nephtrotox.(

Utility: Nosocomial aerobic gram- infects, esp. in immunocomp, neutropenics. Often used in synergistic combs to treat P. aeruginosa, enteroccus, life-threatening gram- sepsis. Used in comb. against S. aureus. Ineffective against anaerobes.

Special Features: Resistance 1° due to plasmid-med. mod. of aminoglyc. Also alter. of transport system, mutation of rib. subunit. Least susceptible to resistance of the aminoglycs. Also, broadest spectrum. Most expensive aminoglyc.

Name: Tobramycin (Nebcin)

Class: Aminoglycoside

Mech.: O2 dependent uptake ® inhib. of protein synth by binding to 30S rib. subunit ® leaky membranes. Bactericidal.

Absorption: Poor oral absorption. Usu. IM or IV.

Distribution: Limited to extracellular space. Poor CSF, ocular. No placenta.

Excretion, t½: glomerular filtration. 2 hrs.

Toxicity/S.E.s: Ototoxicity (aud., vest.), nephtrotoxicity (less than gentamicin).

Utility: Nosocomial aerobic gram- infects, esp. in immunocomp, neutropenics. Often used in synergistic combs to treat P. aeruginosa, enteroccus, life-threatening gram- sepsis. Used in comb. against S. aureus. Ineffective against anaerobes.

Special Features: Resistance 1° due to plasmid-med. mod. of aminoglyc. Also alter. of transport system, mutation of rib. subunit.

Name: Gentamicin (Garamycin)

Class: Aminoglycoside

Mech.: O2 dependent uptake ® inhib. of protein synth by binding to 30S rib. subunit ® leaky membranes. Bactericidal.

Absorption: Poor oral absorption. Usu. IM or IV.

Distribution: Limited to extracellular space. Poor CSF, ocular. No placenta.

Excretion, t½: glomerular filtration. 2 hrs.

Toxicity/S.E.s: Ototoxicity (aud., vest.), nephtrotoxicity.

Utility: Nosocomial aerobic gram- infects, esp. in immunocomp, neutropenics. Often used in synergistic combs to treat P. aeruginosa, enteroccus, life-threatening gram- sepsis. Used in comb. against S. aureus. Ineffective against anaerobes.

Special Features: Resistance 1° due to plasmid-med. mod. of aminoglyc. Also alter. of transport system, mutation of rib. subunit.

Name: Neomycin (Mycifradin)

Class: Aminoglycoside

Mech.: O2 dependent uptake ® inhib. of protein synth by binding to 30S rib. subunit ® leaky membranes. Bactericidal.

Absorption: Very little oral absorption. Topical.

Distribution: Limited to extracellular space. Poor CSF, ocular. No placenta.

Excretion, t½:

Toxicity/S.E.s: Parenteral ® severe ototoxicity and nephrotoxicity.

Utility: Topical treatment of superf. sensitive skin and eye infections. Preoperative prophylaxis for bowel surgery.

Special Features: Resistance 1° due to plasmid-med. mod. of aminoglyc. Also alter. of transport system, mutation of rib. subunit.

Name: Streptomycin

Class: Aminoglycoside

Mech.: O2 dependent uptake ® inhib. of protein synth by binding to 30S rib. subunit ® leaky membranes. Bactericidal.

Absorption: Poor oral absorption. Usu. IM or IV.

Distribution: Limited to extracellular space. Poor CSF, ocular. No placenta.

Excretion, t½: glomerular filtration. 2 hrs.

Toxicity/S.E.s: Ototoxicity. Vestibular toxicity. Low nephrotoxicity.

Utility: Used in comb. therapy for tuberculosis. Used alone for bubonic plague and tularemia.

Special Features: Resistance 1° due to plasmid-med. mod. of aminoglyc. Also alter. of transport system, mutation of rib. subunit.