Showing posts with label Antacid. Show all posts
Showing posts with label Antacid. Show all posts

Calcium Carbonate (Tums, Rolaids)

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Name: Calcium Carbonate (Tums, Rolaids)

Class: Antacid

Mechanism: Weak base ® ¯ gastric acidity. ­ pH ® ¯ peptic activity.

Absorption:

Dist.:

Metabolism.:

Excretion, :

Toxicity/S.E.s:

Utility: PUD

Special Features: Counterproductive—Ca2+ stimulates gastrin release.

 

Magnesium Hydroxide (Milk of Magnesia)

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Name: Magnesium Hydroxide (Milk of Magnesia)

Class: Antacid

Mechanism: Weak base ® ¯ gastric acidity. ­ pH ® ¯ peptic activity.

Absorption:

Dist.:

Metabolism.:

Excretion, :

Toxicity/S.E.s: Diarrhea.

Utility: PUD

Special Features:

 

Al-Mg Hydroxides

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Name: Al-Mg Hydroxides

Class: Antacid

Mechanism: Weak base ® ¯ gastric acidity. ­ pH ® ¯ peptic activity.

Absorption:

Dist.:

Metabolism.:

Excretion, :

Toxicity/S.E.s: Al3+ can form insoluble complexes w/other drugs ® ¯ absorption (e.g., tetracycline).

Utility: PUD

Special Features: Comb. of constipation (Al) and laxative (Mg) effects may cancel ® rel. normal bowel function.

 

Aluminum Hydroxide (Maalox)

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Name: Aluminum Hydroxide (Maalox)

Class: Antacid

Mechanism: Weak base ® ¯ gastric acidity. ­ pH ® ¯ peptic activity.

Absorption:

Dist.:

Metabolism.:

Excretion, :

Toxicity/S.E.s: Constipation. Al3+ can form insoluble complexes w/other drugs ® ¯ absorption (e.g., tetracycline).

Utility: PUD

Special Features: