Name: Captopril (Capoten)
Class: ACE Inhibitor
Mechanism: Inhib. production of angiotensin II ® block of vasoconstriction and aldosterone stim. ® ¯ TPR, ¯ Na+/H20 retention ® ¯ BP. Also blocks inactivation of bradykinin ® vasodilation. Diminishes normal in epinephrine and aldosterone seen in CHF.
Absorption:
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Postural hypotension, renal insufficiency, hyperkalemia, persistent dry cough, rash, angioneurotic edema. C/i in 2nd & 3rd trimesters of pregnancy. Prob. not a great idea for 1st trimester either.
Utility: Treat HTN, CHF, MI.
Special Features: