Name: Gemfibrozil (Lopid) mnemonic
Class: Blood Lipid-Lowering Agent (Fibric Acid Derivative)
Mechanism: catabolism of VLDL, in part 2° to activity of lipoprotein lipase in adipose tissue. Moderate ¯ in TG & VLDL. Mild ¯ in LDL and cholesterol. Moderate in HDL.
Absorption:
Dist.:
Metabolism.: Glucuronide conjugation.
Excretion, t½: Renal excretion.
Toxicity/S.E.s: Generally well tolerated. GI distress, rash, musculoskeletal pain, blurred vision, anemia, leukopenia, gallstones. Adjust dose in pts. w/renal insufficiency.
Utility: DOC for hyperlipidemia III. Better tolerated than niacin for type IV, although less effective. Decreases frequency of CHD-related incidents.
Special Features: