Neomycin (Mycifradin) -|- Pharmacology Mnemonics - Flash Cards

Neomycin (Mycifradin)

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Name: Neomycin (Mycifradin)

Class: Aminoglycoside

Mech.: O2 dependent uptake ® inhib. of protein synth by binding to 30S rib. subunit ® leaky membranes. Bactericidal.

Absorption: Very little oral absorption. Topical.

Distribution: Limited to extracellular space. Poor CSF, ocular. No placenta.

Excretion, t½:

Toxicity/S.E.s: Parenteral ® severe ototoxicity and nephrotoxicity.

Utility: Topical treatment of superf. sensitive skin and eye infections. Preoperative prophylaxis for bowel surgery.

Special Features: Resistance 1° due to plasmid-med. mod. of aminoglyc. Also alter. of transport system, mutation of rib. subunit.