Name: Astemizole (Hismanal)
Class: H1-Histamine Antagonist
Mech.: Competitive inhib. of histamine and histamine receptor interaction.
Absorption:
Dist.: No CNS
Metab.:
Excretion, t½: 10-20 days
Toxicity/S.E.s: Increased appetite, weight gain. Overdose ® cardiac arrhythmia.
Utility: Effective against allergic rhinitis and chronic urticaria.
Special Features: No anticholinergic activity.