Name: Colchicine
Class: Anti-Gout Agent
Mechanism: Binds to tubulin ® inhib. of leukocyte migration & phagocytosis ®
¯ inflamm. response.
Absorption: Rapidly absorbed orally.
Dist.:
Metabolism.:
Excretion, t½: Urine & feces.
Toxicity/S.E.s: GI intolerance (n/v/d).
Utility: Treat acute gout attacks. Use to prevent acute attacks while initiating allopurinol or probenecid therapy.
Special Features: Not analgesic. No effect on uric acid production or excretion.