Name: Probenecid (Benemid)
Class: Anti-Gout Agent (Uricosuric Agent)
Mechanism: Blocks proximal tubular reabsorption of uric acid.
Absorption:
Dist.:
Metabolism.:
Excretion, t½: Reabsorbed by renal tubules & Metabolismolized slowly.
Toxicity/S.E.s: GI irritation (not severe). Skin rash. Rare aplastic anemia.
Utility: Treat gout via increased urinary excretion of uric acid. Blocks tubular secretion of penicillin; may be used to increase penicillin levels.
Special Features: At low doses, probenecid blocks proximal tubule secretion of uric acid.