Name: OKT3 (Muromonab-CD3)
Class: Immunosuppressant
Mechanism: Opsonizes T cells, modulates CD3 antigen recognition complex on T cells, blocks CTL killer function.
Absorption: IV
Dist.:
Metabolism.:
Excretion, t½:
Toxicity/S.E.s: Chills, fever, thrombocytopenia, erythema, pruritis, hypersensitivity rxns, anti-OKT3 antibody production (\ only given for 1-2 weeks).
Utility: Prevent or reverse acute allograft rejection.
Special Features: Murine monoclonal antibody against CD3 on T cells.